Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect

davidd submitted, created time 10 months 6 days (nar.oxfordjournals.org)

This may be the first example in which the off-target effect of an siRNA is actually responsible for the anticipated effect by acting to reduce expression of a protein (TNFR1) that normally regulates expression of the intended target (ICAM-1).

1 comment | Blog It | Email It | Keywords: knockdown gene knockdown gene expression gene regulation off-target effects TNFR1 siRNA