In lung cancer, silencing one crucial gene disrupts normal functioning of genome

piggy submitted, created time 1 week 20 hours (www.eurekalert.org)

While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. They say that the "silencing" of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression

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Oncogenesis: It's all about translation

sea-maid submitted, created time 4 weeks 16 hours (www.nature.com)

The oncogene MYC regulates many cellular processes, making it difficult to pin down its precise function in driving tumor development. Maria Barna, David Ruggero and colleagues suggest that changes to cap-dependent and cap-independent translation during mitosis are pivotal.

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PML targeting eradicates quiescent leukaemia-initiating cells.

kavin submitted, created time 7 months 3 weeks (www.ncbi.nlm.nih.gov)

In this paper, the researchers define the critical role of the promyelocytic leukaemia protein (PML) tumor suppressor in hematopoietic stem cell maintenance, and present a new therapeutic approach for targeting quiescent leukemia-initiating cells and possibly cancer-initiating cells by pharmacological inhibition of PML.

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