Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

kavin submitted, created time 7 months 1 week (www.ncbi.nlm.nih.gov)

Here the authors show that a large proportion of genes controlled synergistically by loss-of-function p53 and Ras activation are critical to the malignant state of murine and human colon cells. Notably, 14 out of 24 'cooperation response genes' were found to contribute to tumour formation in gene perturbation experiments. In contrast, only 1 in 14 perturbations of the genes responding in a non-synergistic manner had a similar effect

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