Articles with the keyword: 
Cancer Cell "Bodyguard" Turned into Killer
piggy submitted, created time 23 hours 37 minutes (www.sciencedaily.com)
If you're a cancer cell, you want a protein called Bcl-2 on your side because it decides if you live or die. It's usually a trusted bodyguard, protecting cancer cells from programmed death and allowing them to grow and form tumors. But sometimes it turns into their assassin.
Scientists knew it happened, but they didn't know how to actually cause such a betrayal. Now they do. And it may lead to the development of new cancer-fighting drugs.
Researchers at Oregon State University and the Burnham Institute for Medical Research in La Jolla, Calif 
Boost for work on deadliest forms of cancer
sea-maid submitted, created time 2 days 3 hours (www.nature.com)
Cancer Research U.K. is to fund more work on pancreatic, lung and esophageal cancer and open up to twenty more centers as part of plans to spend £1.5 billion (U.S. $2.3 billion) over the next five years. The charity, the leading funder of cancer research in the United Kingdom, will also spend more money researching radiotherapy and cancer surgery.
Although the number of people diagnosed with cancer continues to rise, mortality rates have declined since the mid 1980s. Yet pancreatic, lung and oesophageal cancers are still fatal in most cases
Novartis could cut drug development by a year
piggy submitted, created time 1 week 3 days (www.reuters.com)
A new way of conducting clinical trials could allow Novartis AG to cut the time needed to develop some drugs by a year, the Swiss drug maker's designated development head said on Wednesday.
The new approach, which uses disease models to predict measurable markers and responses, could apply in areas like oncology and genetic diseases and allow mid-stage trials to be shortened or even, in some cases, omitted completely.
Hmga directs tumor suppressors in stem cell aging
jerry submitted, created time 1 month 1 week (www.cell.com)
Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16Ink4a. We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that expression declines with age. This decrease is partly caused by the increasing expression of let-7b microRNA, which is known to target HMGA2
Discovery of natural compounds that could slow blood vessel growth
sea-maid submitted, created time 1 month 3 weeks (esciencenews.com)
Using a whole-genome approach, researchers have found more than one hundred human protein compounds that can slow blood vessel growth. This could lead to treatments against diseases that depend on the growth of new blood vessels, including cancer, macular degeneration and rheumatoid arthritis.
Study suggests some breast cancer patients facing radiation after a mastectomy may be over-treated
sea-maid submitted, created time 2 months 1 week (esciencenews.com)
A new study suggests standard radiation therapy for some breast cancer patients may not be medically required and may, therefore, be causing unnecessary serious side effects such as lymphedema and pulmonary problems. The research conducted at Fox Chase Cancer Center involved women who got a mastectomy, but whose lymph nodes were negative. "When a woman has a tumor greater than five centimeters and negative lymph nodes, a mastectomy followed by radiation is recommended," said Penny Anderson, M.D., attending physician in the radiation oncology department at Fox Chase
Angiotensin II blockade may reduce risk of skin carcinoma
kavin submitted, created time 2 months 3 weeks (www.oncolink.org)
Use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) appears to lower the incidence of basal cell and squamous cell carcinoma among people at high risk, according to a study among U.S. veterans.
Evidence from in vivo and in vitro studies suggests that angiotensin II is a potent angiogenic and growth factor, Dr. Jennifer B. Christian and co-investigators note in the September 3 Journal of the National Cancer Institute, issued online on August 26
Genome analysis used to decode brain cancer: study
sea-maid submitted, created time 2 months 3 weeks (afp.google.com)
U.S. scientists have unveiled the most complete genetic profile ever attempted of glioblastoma, a common and deadly form of the brain cancer that U.S. Senator Edward Kennedy is battling.
Virus helps show how cancer spreads
sea-maid submitted, created time 4 months 2 weeks (news.bbc.co.uk)
Scientists have used a common cold virus to "light up" prostate cancer tumors in different parts of the body. A University of California team has found that, when infected by a certain virus, mouse prostate cancer cells become remarkably easy to spot on scanners.
The research team says that the technique requires further development, but if these results extrapolate to humans, it could be a huge boon to cancer research, particularly in cases in which metastasis is suspected.
Melanoma Cured 100% through Blood Cell Therapy
kavin submitted, created time 5 months 1 week (www.efluxmedia.com)
The results of a new study conducted by a researcher team at the Fred Hutchinson Cancer Research Center in Seattle, give hope for those suffering from melanoma, one of the rarer types of skin cancer but the one which causes the majority of skin cancer related deaths.
Researchers who took part in the study used a patient's cloned T cells (helper cells) to put an advanced cancer into complete remission. Nine patients took part in the experimental melanoma treatment program.
The researchers were very surprised after they treated a 52-year-old man from Oregon of his Stage 4 melanoma
The IB kinase – a bridge between inflammation and cancer
davidd submitted, created time 8 months 3 weeks (www.nature.com)
A potential link between inflammation and cancer has been suspected for over a century, but the exact molecular mechanisms connecting the two remained nebulous. The review proposed that NF-B transcription factors regulated via the IB kinase (IKK) complex play a critical role in coupling inflammation and cancer and have set out to test this hypothesis in mouse models of cancer.
genes are differentially regulated in normal and cancer cells
davidd submitted, created time 10 months 6 days (www.pnas.org)
The article reports the results of genome-wide expression profiling experiments on synchronized primary human foreskin fibroblasts across the cell cycle. They identify 480 periodically expressed genes in primary human foreskin fibroblasts. Analysis of the reconstructed primary cell profiles and comparison with published expression datasets from synchronized transformed cells reveals a large number of genes that cycle exclusively in primary cells. This conclusion was supported by both bioinformatic analysis and experiments performed on other cell types
stephen submitted, created time 1 year 2 months (www.pnas.org)
Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR) effect, previous studies using nanoparticles to deliver chemotherapeutics or siRNA demonstrated that attachment of cell-specific targeting ligands to the surface of nanoparticles leads to enhanced potency relative to nontargeted formulations.
Commentary highlights impact of food-cancer drug interactions
bianjie submitted, created time 1 year 4 months (www.eurekalert.org)
A commentary in the Journal of Clinical Oncology, urges researchers to explore an intriguing approach to reduce the dose and therefore the cost, of oral targeted cancer therapies.
Erythropoietin, the FDA, and Oncology
psychologist submitted, created time 1 year 5 months (content.nejm.org)
As has been the case for patients with chronic renal failure, treatment with erythropoiesis-stimulating agents (ESAs) has substantially raised the hemoglobin concentrations of hundreds of thousands of patients with cancer, diminishing their need for red-cell transfusions during chemotherapy
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