Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53

cappuccion submitted, created time 1 year 8 months (www.nature.com)

Oncostatin M (OSM), a cytokine of the interleukin-6 family, induces growth arrest and differentiation of osteoblastic cells into glial-like/osteocytic cells. Here, we asked whether OSM regulates apoptosis of normal or transformed (osteosarcoma) osteoblasts. We show that OSM sensitizes cells to apoptosis induced by various death inducers such as staurosporine, ultraviolet or tumor necrosis factor-alpha.

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