Reversine increases the plasticity of lineage-committed mammalian cells

addict submitted, created time 1 year 6 months (www.pnas.org)

Previously, a small molecule, reversine, was identified that reverses lineage-committed murine myoblasts to a more primitive multipotent state. Here, we show that reversine can increase the plasticity of C2C12 myoblasts at the single-cell level and that reversine-treated cells gain the ability to differentiate into osteoblasts and adipocytes under lineage-specific inducing conditions.

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Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53

cappuccion submitted, created time 1 year 8 months (www.nature.com)

Oncostatin M (OSM), a cytokine of the interleukin-6 family, induces growth arrest and differentiation of osteoblastic cells into glial-like/osteocytic cells. Here, we asked whether OSM regulates apoptosis of normal or transformed (osteosarcoma) osteoblasts. We show that OSM sensitizes cells to apoptosis induced by various death inducers such as staurosporine, ultraviolet or tumor necrosis factor-alpha.

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HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes

alpha submitted, created time 1 year 8 months (mcb.asm.org)

"HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown."

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Murine osteoblasts regulate mesenchymal stem cells via WNT and cadherin pathways: mechanism depends on cell-cell contact mode

BIOBOSS submitted, created time 1 year 8 months (www3.interscience.wiley.com)

Osteoblasts (OSTs) are derived from mesenchymal stem cells (MSCs) and coexist in close proximity with MSCs in bone during development and remodelling. Interactions between these two cell types remain obscure.

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