Cancer reveals cruel trick

sea-maid submitted, created time 6 months 3 weeks (www.nature.com)

Some tumours may stimulate the growth of distant cancers within the body. And it is very important for us to know this. We can take some measures to prevent the cancer efficiently. This article discusses some of the forms of early metastasis and tumor promotion by other tumors.

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Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production

kitty submitted, created time 1 year 4 months (www.pnas.org)

Osteopontin (OPN), a multifunctional secreted phosphoglycoprotein, plays diverse roles in bone biology, immune regulation, cell survival, inflammation, and cancer metastasis.

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Study identifies key player in the body's immune response to chronic stress

sumsung submitted, created time 1 year 4 months (www.eurekalert.org)

Osteopontin, a protein molecule involved in many different cellular processes, plays a significant role in immune deficiency and organ atrophy following chronic physiological stress such as spaceflight, resulting in increased susceptibility to illness.

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Heterozygous Disruption of the PTEN Promotes Intestinal Neoplasia in APCmin/+ Mouse: Roles of Osteopontin

jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)

our results suggest that the PI3K pathway promotes the transformation of intestinal adenoma to adenocarcinoma. Osteopontin, a downstream effector of PI3K, protects transformed intestinal epithelial cells from programmed cell death and stimulates their anchorage-independent growth.

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