The coding polymorphism T263I in TGF-ß1 is associated with otosclerosis in two independent populations

penguin submitted, created time 1 year 6 months (hmg.oxfordjournals.org)

Otosclerosis is a progressive hearing loss characterized by an abnormal bone homeostasis of the otic capsule that leads to stapes fixation. Although its etiology remains unknown, otosclerosis can be considered a complex disease. Transforming growth factor beta 1 (TGF-ß1) was chosen for a case-control association study, because of several non-genetic indications of involvement in otosclerosis. SNP analysis in a large Belgian-Dutch sample set gave significant results (p = 0.0044) for an amino acid changing SNP, T263I

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Scientists Identify Hearing Loss Gene

crackpot submitted, created time 1 year 6 months (www.forbes.com)

Belgian scientists have identified a gene variant that causes otosclerosis, the single most common cause of hearing loss among white adults. The finding may lead to new treatments for the condition, which affects about one in 250 people.

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