Gonadotropins and Ovarian Cancer

DanyC submitted, created time 1 year 7 months (edrv.endojournals.org)

"Ovarian carcinomas have been found to express specific receptors for gonadotropins. The presence of gonadotropins in ovarian tumor fluid suggests the importance of these factors in the transformation and progression of ovarian cancers as well as being prognostic indicators. Functionally, there is evidence showing a direct action of gonadotropins on ovarian tumor cell growth. This review summarizes the key findings and recent advances in our understanding of these peptide hormones in ovarian cancer development and progression and their role in potential future cancer therapy

Submit comment | Blog It | Email It | Keywords: ovarian cancers Ovarian Stem Cells gonadotropins

How to find hypermethylated genes from genome

big pig submitted, created time 1 year 10 months (bioinformatics.oxfordjournals.org)

Scientists developed a general method, cluster_boost, that in an imbalanced data setting predicts new minority class members given limited known samples and a large set of unlabeled samples. Synthetic datasets modeled after the hypermethylated genes data show that cluster_boost can successfully identify minority samples within unlabeled data. Using genome sequence features, cluster_boost predicted candidate hypermethylated genes among 14 000 genes of unknown status

Submit comment | Blog It | Email It | Keywords: cluster boost genome ovarian cancers hypermethylated genes