Frequent p16-Independent Inactivation of p14ARF in Human Melanoma

kavin submitted, created time 7 months 3 days (jnci.oxfordjournals.org)

In this paper, the authors observed two or more alterations to the ARF gene in 26/60 (43%) metastases. The p16 gene sustained two or more alterations in 13/60 (22%) metastases (P = .03). Inactivation of ARF in the presence of wild-type p16 was seen in 18/60 (30%) metastases. And the genetic and epigenetic analyses of the human 9p21 locus indicate that modifications of ARF occur independently of p16 inactivation in human melanoma and suggest that ARF is more frequently inactivated than p16.

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Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)

Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its overexpression in many types of human cancer and its positive role in promoting cell survival. The aim of this study was to investigate the role of TWIST on the growth of human epithelial cells.

1 comment | Blog It | Email It | Keywords: TWIST p14ARF senescence epithelial cells