Frequent p16-Independent Inactivation of p14ARF in Human Melanoma

kavin submitted, created time 7 months 3 days (jnci.oxfordjournals.org)

In this paper, the authors observed two or more alterations to the ARF gene in 26/60 (43%) metastases. The p16 gene sustained two or more alterations in 13/60 (22%) metastases (P = .03). Inactivation of ARF in the presence of wild-type p16 was seen in 18/60 (30%) metastases. And the genetic and epigenetic analyses of the human 9p21 locus indicate that modifications of ARF occur independently of p16 inactivation in human melanoma and suggest that ARF is more frequently inactivated than p16.

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Inactivation of Myocardin and p16 and a Differentiation Defect during Malignant Transformation

cappuccion submitted, created time 1 year 9 months (www.sciencedirect.com)

Myocardin is known as an important transcriptional regulator in smooth and cardiac muscle development. It is frequently repressed during human malignant transformation, contributing to a differentiation defect. In this research, the scientists demonstrated that myocardin is a transcriptional target of TGFβ required for TGFβ-mediated differentiation of human fibroblasts. Serum deprivation, intact contact inhibition response, and the p16ink4a/Rb pathway contribute to myocardin induction and differentiation

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