Hmga directs tumor suppressors in stem cell aging

jerry submitted, created time 2 months 2 weeks (www.cell.com)

Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16Ink4a. We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that expression declines with age. This decrease is partly caused by the increasing expression of let-7b microRNA, which is known to target HMGA2

Submit comment | Blog It | Email It | Keywords: p16Ink4a p19Arf tumors cancer oncology aging transcriptional regulators tumor suppressors Hmga

Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

sea-maid submitted, created time 2 months 2 weeks (www.sciencedirect.com)

Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16Ink4a. We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that expression declines with age. This decrease is partly caused by the increasing expression of let-7b microRNA, which is known to target HMGA2

1 comment | Blog It | Email It | Keywords: microRNA miRNA let-7b Hmga2 p19Arf tumors p16Ink4a cancer stem cell research stem cells aging senescence

Rethinking the Wrinkling: Key Genes Cause Aging

jerry submitted, created time 3 months 2 weeks (www.sciam.com)

Scientists may have been thinking about the causes of aging all wrong. Instead of being the result of an accumulation of genetic and cellular damage, new evidence suggests that aging may occur when genetic programs for development go awry.

1 comment | Blog It | Email It | Keywords: oxidative stress stress free radicals p16INK4a cellular damage aging