Articles with the keyword: 
Most common brain cancer may originate in neural stem cells
piggy submitted, created time 9 months 2 weeks (www.eurekalert.org)
University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future treatments and a way to screen for the disease early.
Appearing June 2 in Cancer Cell, the U-M team's findings in mice show for the first time that:
Glioblastoma, the type of cancer that afflicts U.S. Sen 
Cellular discovery may lead to targeted treatment for rare form of anemia
piggy submitted, created time 1 year 4 days (www.eurekalert.org)
University of Cincinnati (UC) researchers have identified the specific biological mechanisms believed to lead to a rare and incurable blood disease known as Diamond Blackfan anemia (DBA). Scientists say with further investigation, their discoveries could result in drastic changes to current thinking about treatment for this disease and may lead to promising new drug therapies.
George Thomas, PhD, Stefano Fumagalli, PhD, and collaborators report their findings online ahead of print in the journal Nature Cell Biology on Sunday, March 15, 2009
Tool Analyzes Function of Crucial Set of Proteins in Animals
sea-maid submitted, created time 1 year 1 month (www.sciencedaily.com)
University of Saskatchewan scientists have developed a new tool that enables scientists to analyze the function of a crucial set of proteins in animals—a finding that could lead to a host of better drugs for and deeper insights into the workings of cancer.
Selenium may prevent high-risk bladder cancer
piggy submitted, created time 1 year 3 months (www.eurekalert.org)
A study published in the December issue of Cancer Prevention Research, a journal of the American Association for Cancer Research, suggests that selenium, a trace mineral found in grains, nuts and meats, may aid in the prevention of high-risk bladder cancer.
Researchers from Dartmouth Medical School compared selenium levels in 767 individuals newly diagnosed with bladder cancer to the levels of 1,108 individuals from the general population. Findings showed an inverse association between selenium and bladder cancer among women, some smokers and those with p53 positive bladder cancer
jerry submitted, created time 1 year 9 months (www.genesdev.org)
Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis. This research provided a valuable platform for addressing the molecular genetics of osteosarcoma and for developing novel therapeutic strategies.
DNA Damage Signals for p53 Pulses
jerry submitted, created time 1 year 9 months (www.sciencedirect.com)
A major challenge of systems biology is to understand how network topology affects protein dynamics in living cells. A new study show that p53 pulses are driven by pulses in the upstream signaling kinases, ATM and Chk2, and that a negative feedback mediated by the phosphatase Wip1 is essential for maintaining the uniform shape of p53 pulses.
Acetylation Is Indispensable for p53 Activation
kavin submitted, created time 1 year 10 months (www.cell.com)
The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished. This study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response.
p53 Activation: A Case against Sir
jerry submitted, created time 1 year 10 months (www.cancercell.org)
The p53 tumor suppressor is a critical transcription factor for controlling cell growth and apoptosis during times of cellular stress.
In this issue, the researchers screened small-molecule activators of p53 that could potentially reduce tumor growth Tenovin-6 was identified as a potent SIRT1 and SIRT2 inhibitor that indirectly activated p53 at single-digit micromolar concentrations.
The identification of a specific sirtuin inhibitor has broad implications in understanding sirtuin-p53 signaling and the development of novel chemotherapeutics
Cancer Drug -- Promising New Design Found
DanyC submitted, created time 2 years 1 week (health.usnews.com)
A drug that targets a protein interaction involved in many types of cancer has been created by University of Michigan researchers.
PS:
Many traditional cancer drugs also activate p53, but they do so by causing DNA damage.
Updates on p53: modulation of p53 degradation as a therapeutic approach
DanyC submitted, created time 2 years 2 months (www.nature.com)
"The p53 pathway is aberrant in most human tumors with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 activity for cancer therapy."
Cancer Fighter May Be Fertility Helper
Eric wu submitted, created time 2 years 3 months (sciencenow.sciencemag.org)
A protein known primarily for its role in fighting cancer also helps embryos implant in the womb, according to a study in mice. The find may explain why some women have difficulty becoming pregnant.
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis
carly submitted, created time 2 years 5 months (www.pnas.org)
A recently discovered phosphatidylinositol monophosphate, phosphatidylinositol 5-phosphate (PtdIns-5-P), plays an important role in nuclear signaling by influencing p53-dependent apoptosis. It interacts with a plant homeodomain finger of inhibitor of growth protein-2, causing an increase in the acetylation and stability of p53.
sumsung submitted, created time 2 years 5 months (www.pnas.org)
Cancer is a disease of aging. The accumulation of mutations in individual cells over a lifetime is thought to be the reason. In this work, we explored an additional hypothesis: could p53 function decline with age, which would contribute to an enhanced mutation frequency and tumorigenesis in the aging process.
Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis
DanyC submitted, created time 2 years 5 months (www.cell.com)
"Researchers report that eliminating HSF1 protects mice from tumors induced by mutations of the RAS oncogene or a hot spot mutation in the tumor suppressor p53. In cell culture, HSF1 supports malignant transformation by orchestrating a network of core cellular functions including proliferation, survival, protein synthesis, and glucose metabolism
june submitted, created time 2 years 5 months (www.medicalnewstoday.com)
UroToday.com- Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis. APF is detectable in the urine of 95% of IC patients as compared to approximately 9% of controls and is also a low molecular weight glycosylated peptide related to the membrane receptor frizzled 8
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