p53 Activation: A Case against Sir

jerry submitted, created time 6 months 1 week (www.cancercell.org)

The p53 tumor suppressor is a critical transcription factor for controlling cell growth and apoptosis during times of cellular stress.

In this issue, the researchers screened small-molecule activators of p53 that could potentially reduce tumor growth Tenovin-6 was identified as a potent SIRT1 and SIRT2 inhibitor that indirectly activated p53 at single-digit micromolar concentrations.

The identification of a specific sirtuin inhibitor has broad implications in understanding sirtuin-p53 signaling and the development of novel chemotherapeutics

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ß1-Adrenergic Receptor Autoantibodies Mediate Dilated Cardiomyopathy by Agonistically Inducing Cardiomyocyte Apoptosis

Reviver submitted, created time 1 year 2 months (circ.ahajournals.org)

"These events led to functional alterations in intracellular calcium handling and contractile function. Sustained agonism by ß1AR autoantibodies elicited caspase-3 activation, cardiomyocyte apoptosis, and DCM in vivo, and these processes were prevented by in vivo treatment with the pan-caspase inhibitor Z-VAD-FMK."

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Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

Reviver submitted, created time 1 year 5 months (www.molecule.org)

"p53 is a potent tumor suppressor, whose biological effects are largely due to its function as a transcriptional regulator. Here researchers report that, in addition to regulating the expression of hundreds of protein-coding genes, p53 also modulates the levels of microRNAs (miRNAs). Specifically, p53 can induce expression of microRNA-34a (miR-34a) in cultured cells as well as in irradiated mice, by binding to a perfect p53 binding site located within the gene that gives rise to miR-34a. Processing of the primary transcript into mature miR-34a involves the excision of a 30 kb intron

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