Enzyme May Hold Key to Successfully Treating Pancreatic Cancer with Targeted Immunotherapy,

sea-maid submitted, created time 4 weeks 15 hours (www.sciencedaily.com)

An enzyme that is overexpressed in pancreatic cancer cells may hold the key to successfully treating the disease with targeted immunotherapy, researchers from Thomas Jefferson University reported at the 2008 Annual Meeting of the Southern Surgical Association.

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Researchers Discover Achilles' Heel in Pancreatic Cancer

sea-maid submitted, created time 1 month 4 weeks (gopast.net)

UC Davis Cancer Center researchers have discovered a metabolic deficiency in pancreatic cancer cells that can be used to slow the progress of the deadliest of all cancers.

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What You Need to Know About Mapping the Cancer Genome

jerry submitted, created time 4 months 23 hours (health.usnews.com)

By Katherine Hobson Two of the most feared cancer diagnoses are glioblastoma, the most aggressive kind of brain tumor, and pancreatic cancer.

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Five new proteins for detecting pancreatic cancer early

kavin submitted, created time 6 months 2 weeks (medicine.plosjournals.org)

NEW YORK (Reuters Health) Jun 18 - Proteins differentially expressed in a mouse model of pancreatic ductal adenocarcinoma are also present in early-stage disease in humans, scientists report in the June issue of PLoS Medicine.

"There is a compelling need to develop blood-based markers that allow early cancer detection, classify tumors to direct therapy, and monitor disease progression, regression, or recurrence," senior author Dr. Samir M. Hanash, at the Fred Hutchinson Cancer Research Center in Seattle, and his colleagues write

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Equivalent of a death sentence : Pancreatic cancer

DanyC submitted, created time 10 months 2 days (www.stuff.co.nz)

Woo...I have shocked by such new, anyone, who have heard such like below:
Most pancreatic cancer patients are dead within the first year.
Common symptoms of the cancer include appetite loss, weight loss, upset stomach and nausea. The most common physical sign can be jaundice.

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treatment clues for pancreatic cancer

jane2007 submitted, created time 10 months 2 weeks (www.bcm.edu)

Mesothelin that is found on the tumor cells' surface appears to play an important role in promoting pancreatic cancer growth. Making a treatment vaccine of virus-like particles (VLPs) that contained mesothelin could lead to a new vaccine against the deadly disease.

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RAS/ERK Modulates TGFß-regulated PTEN Expression In Human Pancreatic Adenocarcinoma Cells

jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)

PTEN is rarely mutated in pancreatic cancers, but its regulation by TGFß might mediate growth suppression and other oncogenic actions. Here, we examined the role of TGFß and the effects of oncogenic K-RAS/ERK upon PTEN expression in the absence of SMAD4. We utilized two SMAD4-null pancreatic cell lines, CAPAN-1 (K-RAS mutant) and BxPc-3 (WT-K-RAS), both of which express TGFß surface receptors.

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Transcriptional network governing the angiogenic switch in human pancreatic cancer

bianjie submitted, created time 1 year 5 months (www.pnas.org)

A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression. Here we devise a strategy for identifying genetic participants of the angiogenic switch based on inverse regulation of genes in human endothelial cells in response to key endogenous pro- and antiangiogenic proteins.

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Cell receptor may lead to new 'biomarker' for pancreatic cancer

BIOBOSS submitted, created time 1 year 6 months (www.eurekalert.org)

A research team led by University of Cincinnati scientists has identified a potential biological target for pancreatic cancer, a finding they say could help scientists better understand -- and eventually treat -- the disease that kills more than 33,000 people each year.

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Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1

cappuccion submitted, created time 1 year 8 months (www.nature.com)

"Caveolin-1 (Cav-1) is an integral transmembrane protein and a critical component in interactions of integrin receptors with cytoskeleton-associated and signaling molecules. Since integrin-mediated cell adhesion generates signals conferring radiation resistance, we examined the effects of small interfering RNA-mediated knockdown of Cav-1 alone or in combination with beta1-integrin or focal adhesion kinase (FAK) on radiation survival and proliferation of pancreatic carcinoma cell lines."

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