Rosiglitazone-Associated Fractures in Type 2 Diabetes

Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses

captainclaw submitted, created time 1 year 4 months (ajpregu.physiology.org)

"Researchers also sought to determine the relative importance to beta-arrestin recruitment of motifs in the CRF1 receptor carboxyl terminus and third intracellular loop. beta-Arrestin-2 translocated significantly more rapidly than beta-arrestin-1 to agonist-activated membrane CRF1 receptors in multiple cell lines. Although CRF1 receptors internalized with agonist treatment, neither arrestin isoform trafficked with the receptor inside the cell, indicating that CRF1 receptor-arrestin complexes dissociate at or near the cell membrane

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Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia

julie submitted, created time 1 year 7 months (archpsyc.ama-assn.org)

"Volumetric thalamic abnormalities in schizophrenia occur in twin pairs concordant for schizophrenia. These abnormalities may mark the substantial genetic contribution to the illness seen in concordant twin pairs, whereas the adhesio interthalamica is unlikely to be affected in schizophrenia. "

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Mechanisms of Disease: genetics of functional gastrointestinal disorders

seanangel submitted, created time 1 year 8 months (www.nature.com)

'There is evidence to suggest that genetic factors contribute to the manifestation of functional gastrointestinal disorders (FGID). As such, it is important to note that FGID are heterogeneous; they have quite different clinical features and (probably) different underlying pathophysiologic mechanisms.'

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