Peptidase frees receptors in endosomes

dedu submitted, created time 1 year 4 weeks (www.jcb.org)

“Internalized pain receptors are freed up by a peptidase for another round of agony, Padilla et al. reveal.
Peptidases on the cell surface cleave and thereby activate or inactivate small, extracellular peptides such as angiotensin. The enzymes also reside in internal compartments called endosomes, where their action is less apparent.
The new work shows that a peptidase called ECE-1 needs the low pH of the endosome to cleave several of its targets. One such peptide target was CGRP, which is released by cells during inflammation

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