Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells

julie submitted, created time 1 year 7 months (brain.oxfordjournals.org)

"Human embryonic stem cells (hESCs) are a potential source of defined tissue for cell-based therapies in regenerative neurology. In order for this potential to be realized, there is a need for the evaluation of the behaviour of human embryonic stem cell-derived neural stem cells (hES-NSCs) both in the normal and the injured CNS. Using normal tissue and two experimental models, we examined the response of clinically compatible hES-NSCs to physiological and pathological signals

Submit comment | Blog It | Email It | Keywords: human embryonic stem cells neural stem cells temporal maturation phenotypic potential cell