Articles with the keyword: 


Generation of pluripotent stem cells from adult human testis
sea-maid submitted, created time 2 months 3 weeks (www.nature.com)
This is a writeup in Nature of the recent discovery that human and mouse spermatogonial cells can be rendered into pluripotent cell lines with similarities to embryonic stem cells.
"Here we report the successful establishment of human adult germline stem cells derived from spermatogonial cells of adult human testis. Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice 


Stem cells from testicles offer an alternative to embryos
jerry submitted, created time 2 months 4 weeks (ap.google.com)
Cells taken from men's testicles seem as versatile as the stem cells derived from embryos, researchers reported Wednesday in what may be yet another new approach in a burgeoning scientific field. The downside? Because of their source, these cells could only be used for regenerative medicine in male patients, not in female ones.
The study involved twenty-two samples from men aged seventeen to eighty-one. All of them men were undergoing treatments for other reasons 


Regenerative medicine may have just found a shortcut
sea-maid submitted, created time 3 months 1 day (www.nature.com)
Moving from one differentiated cell type from another may not always require a stopover in an undifferentiated state. This paper shows an alternative route to a differentiated state, which may have serious applications in regenerative medicine and provide real-world applications for human embryonic stem cells. 


A natural reprogramming system
sea-maid submitted, created time 4 months 1 week (www.nature.com)
In fruit flies--and presumably other pupating insects--specialized cells revert to multipotency as the larva prepares to transform into an adult. We had thought that the differentiated larval cells simply died during this process, and many of them do, but it does seem that some can regain some pluripotency.
The way they figured this out is particularly vivid. By modifying the cells in the larvae's tracheae to glow green, researchers were able to track their destinations and daughter cells.
We already knew that some human cells were able to perform similar feats 


Stem cells: Embryonic lines from four-cell embryos show pluripotency
Darkfrog submitted, created time 5 months 4 weeks (www.eurekalert.org)
A team in Barcelona has developed a human embryonic stem cell line from one cell of a four-cell blastomere. Although I doubt that particular blastomere was later implanted into a woman, we know from fertility treatments that four-celled embryos that lose one cell during the freeze-thaw process can successfully develop into children. The major accomplishment here is that these stem cell lines do not need to be co-cultured with other cells 


Stem Cells and Early Lineage Development
davidd submitted, created time 10 months 1 week (www.cell.com)
The recent derivation of pluripotent stem cell lines from a number of different sources, including reprogrammed adult somatic cells, raises the issue of the developmental equivalence of these different pluripotent states. At least two different states representing the epiblast progenitors in the blastocyst and the pluripotent progenitors of the later gastrulating embryo have been recognized. Understanding the initial developmental status of the different pluripotent lines is critical for defining starting conditions for differentiation toward therapeutically relevant cell types. 


Human Embryos Cloned From Skin Cells
Eric wu submitted, created time 11 months 2 weeks (sciencenow.sciencemag.org)
A new breakthrough on stem-cell research!
A major breakthrough occurred last year when scientists figured out how to turn skin cells into ES-like cells. But they still want to be able to do cloning, otherwise known as somatic cell nuclear transfer (SCNT), because embryonic cells are the "gold standard" for pluripotent cells--cells that can become any cell type in the body. In addition, scientists want to learn more about how an oocyte can reprogram a mature cell back into an ES cell. 
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