Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

davidd submitted, created time 10 months 2 days (www.nature.com)

Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors.

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Genetic Polymorphism Tied to Sudden Death in Diabetics

kavin submitted, created time 1 year 3 weeks (www.medscape.com)

NEW YORK (Reuters Health) Dec 14 - The cholesterol ester transfer protein (CETP) TaqIB polymorphism is associated with the risk of sudden death in type 2 diabetic patients, according to French researchers.

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Risk factors and myocardial infarction in patients with obstructive sleep apnea: impact of β2-adrenergic receptor polymorphisms

angelfish submitted, created time 1 year 7 months (www.biomedcentral.com)

"The increased sympathetic nervous activity in patients with obstructive sleep apnea (OSA) is largely responsible for the high prevalence of arterial hypertension, and it is suggested to adversely affect triglyceride and high-density lipoprotein (HDL) cholesterol levels in these patients. The functionally relevant polymorphisms of the β2-adrenergic receptor (Arg-47Cys/Arg16Gly and Gln27Glu) have been shown to exert modifying effects on these risk factors in previous studies, but results are inconsistent.....continue"

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PolyScan: An automatic indel and SNP detection approach to the analysis of human resequencing data

Reviver submitted, created time 1 year 9 months (www.genome.org)

"Small insertions and deletions (indels) and single nucleotide polymorphisms (SNPs) are common genetic variants that are thought to be associated with a wide variety of human diseases. Owing to the genome’s size and complexity, manually characterizing each one of these variations in an individual is not practical. While significant progress has been made in automated single-base mutation discovery from the sequences of diploid PCR products, automated and reliable detection of indels continues to pose difficult challenges

Submit comment | Blog It | Email It | Keywords: genetic polymorphisms single-nucleotide polymorphisms (SNPs)