Articles with the keyword: 
sumsung submitted, created time 6 months 3 days (sciencenow.sciencemag.org)
Researchers have unearthed new clues behind a disease that effectively turns young children into senior citizens. A protein called progerin prods stem cells to go astray, causing them to mature into the wrong cell types. The findings may have implications for understanding normal aging as well. 


The reticulons: a family of proteins with diverse functions
zibba submitted, created time 8 months 1 week (genomebiology.com)
The reticulon family is a large and diverse group of membrane-associated proteins found throughout the eukaryotic kingdom. All of its members contain a carboxy-terminal reticulon homology domain that consists of two hydrophobic regions flanking a hydrophilic loop of 60-70 amino acids, but reticulon amino-terminal domains display little or no similarity to each other. 


How were DNA and protein molecules formed during the process of the origin of life?
pang xiaofeng submitted, created time 10 months 2 days (www.discover8.com)
We propose a new mechanism for the formation of DNA and protein molecules in the process of the origin of life based on the discovery of clustered chain structures of water molecules of size 2-70nm which exist in addition to the free molecules present in water. We suggest that not only was water a suitable environment for the appearance of DNA and protein molecules in primordial times but also that water molecules, with their clustered chain structures, were the templates for the formation of DNA and protein molecules 


sumsung submitted, created time 10 months 1 week (www.pnas.org)
Protein quality control is accomplished by inducing chaperones and proteases in response to an altered cellular folding state. In Escherichia coli, expression of chaperones and proteases is positively regulated by δ32. 


brooke submitted, created time 10 months 2 weeks (www.pnas.org)
Ovarian cancer is a leading cause of deaths, yet many aspects of the biology of the disease and a routine means of its detection are lacking. We have used protein microarrays and autoantibodies from cancer patients to identify proteins that are aberrantly expressed in ovarian tissue. 


A search for biomarkers for early detection of colorectal cancer
william submitted, created time 11 months 1 week (www.eurekalert.org)
Using two-dimensional gel electrophoresis, 27 differentially expressed proteins were identified in colorectal adenoma, compared with individual-matched normal mucosa and cancer tissue. In those proteins, the differential expression of two novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validated by Western-blot. This study clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer. 


Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event
davis submitted, created time 11 months 2 weeks (www.pnas.org)
In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7) physiologically phosphorylates mammalian and yeast proteins. 


jackson submitted, created time 11 months 3 weeks (www.pnas.org)
The signal-recognition particle (SRP) is a ubiquitous protein–RNA complex that targets proteins to cellular membranes for insertion or secretion. A key player in SRP-mediated protein targeting is the evolutionarily conserved core consisting of the SRP RNA and the multidomain protein SRP54. 


Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice
stephen submitted, created time 1 year 3 days (www.pnas.org)
Tamalin is a scaffold protein that interacts with metabotropic glutamate receptors and the kinase-deficient neurotrophin TrkCT1 receptor and forms a protein complex with multiple protein-trafficking and intracellular signaling molecules. 


Protein that removes plaque holds promise for Alzheimer's patients
merry submitted, created time 1 year 3 weeks (www.cbc.ca)
Scientists from the University of Rochester Medical Centre in Rochester, N.Y., performed studies on mice with a buildup of amyloid-beta, a toxic plaque that builds up in the brains of Alzheimer's sufferers and damages them. 


Call for EU to launch major project to map out all our proteins
sumsung submitted, created time 1 year 1 month (www.eurekalert.org)
Biologists still have no clear idea how many active genes there are coding for proteins in humans and other organisms, even though for some species the genomes have been completely sequenced. 


New role for protein in fat cells may improve understanding of obesity and diabetes
sumsung submitted, created time 1 year 1 month (www.eurekalert.org)
Scientists have shown for the first time that a protein involved in the transfer of fat in the blood may also influence how fat cells store fat. Richard E. Morton and Lahoucine Izem, research scientists at the Cleveland Clinic Foundation, have shown that the protein, called cholesteryl ester transfer protein, is involved in the cellular storage and regulation of cholesterol and other fats and, as a result, probably has unexpected contributions to obesity and diabetes. 


MIT IDs link between brain tumor proteins
sumsung submitted, created time 1 year 1 month (www.eurekalert.org)
MIT researchers have identified a critical link between two proteins found in brain tumors, a discovery that could eventually help treat a form of brain cancer that kills 99 percent of patients. 


Protein pulling -- Learning how proteins fold by pulling them apart
sumsung submitted, created time 1 year 1 month (www.eurekalert.org)
Rice University physicists have unveiled an innovative way to learn how proteins get their shape based on how they unfold when pulled apart. The experimental method could be of widespread use in the field of protein folding science. 


Protein 4.1B suppresses prostate cancer progression and metastasis
sumsung submitted, created time 1 year 1 month (www.pnas.org)
Protein 4.1B is a 4.1/ezrin/radixin/moesin domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers, and breast carcinomas. 