Interresidue contacts in protein structures and protein complexes

kavin submitted, created time 7 months 2 weeks (www.ncbi.nlm.nih.gov)

The investigation is extended to a set of protein-protein complexes, showing that the similar global rules apply as for intraprotein contacts, with 64% of the interprotein contacts best described by local structures. The authors then present an evaluation of pairing functions integrating structural letters to decoy scoring and show that some complexes could benefit from the use of structural letter-based pairing functions. Proteins 2008. (c) 2008 Wiley-Liss, Inc.

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Rapid and Intermittent Cotransport of Slow Component-b Proteins

alpha submitted, created time 1 year 9 months (www.jneurosci.org)

"After synthesis in neuronal perikarya, proteins destined for synapses and other distant axonal sites are transported in three major groups that differ in average velocity and protein composition: fast component (FC), slow component-a (SCa), and slow component-b (SCb)."

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Genetic disorders implicate a human phenome-interactome network of protein complexes

psychologist submitted, created time 1 year 9 months (www.nature.com)

A systematic, large-scale analysis of human protein complexes are performed comprising gene products implicated in many different categories of human disease to create a phenome-interactome network. It was done by integrating quality-controlled interactions of human proteins with a validated, computationally derived phenotype similarity score, permitting identification of previously unknown complexes likely to be associated with disease

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