A Lipidic-Sponge Phase Screen for Membrane Protein Crystallization

jerry submitted, created time 5 months 3 weeks (www.structure.org)

A major current deficit in structural biology is the lack of high-resolution structures of eukaryotic membrane proteins, many of which are key drug targets for the treatment of disease. Numerous eukaryotic membrane proteins require specific lipids for their stability and activity, and efforts to crystallize and solve the structures of membrane proteins that do not address the issue of lipids frequently end in failure rather than success. To help address this problem, they have developed a sparse matrix crystallization screen consisting of 48 lipidic-sponge phase conditions

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