Enzyme reinforces tumor-causing role of the nuclear coactivator SRC-3

jane2007 submitted, created time 10 months 1 week (www.bcm.edu)

A new study shows, high levels of the enzyme atypical protein kinase C (aPKC) increases the activity of the cancer-associated protein steroid receptor coactivator-3 (SRC-3) in cancer cells that depend on estrogen to promote their growth.

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Analytical biochemistry of DNA–protein assemblies from crude cell extracts

Reviver submitted, created time 1 year 4 months (nar.oxfordjournals.org)

"The purified components were identified as well-known DNA repair proteins, and were shown to retain their enzymatic activities, as seen by monitoring DNA ligation products. Remarkably, kinase activities, also monitored, were found to be distinct on the beads and on the purified DNA–protein complexes, showing the benefits to uncouple the DNA–protein assemblies from the beads for a proper understanding of biochemical regulatory mechanisms involved in the DNA–protein assemblies."

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Protein kinase C and other diacylglycerol effectors in cancer

dovechocolate submitted, created time 1 year 7 months (www.nature.com)

Almost three decades after the discovery of protein kinase C (PKC), we still have only a partial understanding of how this family of serine/threonine kinases is involved in tumour promotion. PKC isozymes — effectors of diacylglycerol (DAG) and the main targets of phorbol-ester tumour promoters — have important roles in cell-cycle regulation, cellular survival, malignant transformation and apoptosis

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Oxidative Stress Causes Renal Dopamine D1 Receptor Dysfunction and Hypertension via Mechanisms That Involve Nuclear Factor-B and Protein Kinase C

alpha submitted, created time 1 year 8 months (jasn.asnjournals.org)

”Renal dopamine, via activation of D1 receptors, plays a role in maintaining sodium homeostasis and BP. There exists a defect in renal D1 receptor function in hypertension, diabetes, and aging, conditions that are associated with oxidative stress. However, the exact underlying mechanism of the oxidative stress–mediated impaired D1 receptor signaling and hypertension is not known. The effect of oxidative stress on renal D1 receptor function was investigated in healthy animals."

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HCN Pacemaker Channel Activation Is Controlled by Acidic Lipids Downstream of Diacylglycerol Kinase and Phospholipase A2

medal submitted, created time 1 year 9 months (www.jneurosci.org)

"Hyperpolarization-activated pacemaker currents (IH) contribute to the subthreshold properties of excitable cells and thereby influence behaviors such as synaptic integration and the appearance and frequency of intrinsic rhythmic activity. Accordingly, modulation of IH contributes to cellular plasticity."

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