Inhibitors of protein kinase CK2.

yarmoluk submitted, created time 10 months 6 days (www.bioorganica.org.ua)

This review presents general data on the CK2 inhibitors of various chemical structure. Protein kinase CK2 (CK2) has long been implicated in the regulation of cell growth and proliferation. The CK2 negative role has also been proven in some mechanisms accompanying cell-controlled apoptosis (anti-apoptotic protecting function). Thus, the CK2 is considered as a perspective target for anticancer drugs

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

davidd submitted, created time 10 months 1 week (www.pnas.org)

B-RAF is the most frequent oncogenic protein kinase mutation known. Furthermore, inhibitors targeting "active" protein kinases have demonstrated significant utility in the therapeutic repertoire against cancer. The article represents the entire discovery process of a selective inhibitor , from initial identification through structural and biological studies in animal models to a promising therapeutic for testing in cancer patients bearing B-RafV600E-driven tumors.

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Key Role for Intracellular K+ and Protein Kinases Sat4/Hal4 and Hal5 in the Plasma Membrane Stabilization of Yeast Nutrient Transporter

sharkboy submitted, created time 1 year 5 months (mcb.asm.org)

"Here we show that these kinases are not required for Trk1 activity; rather, they stabilize the transporter at the plasma membrane under low K+ conditions, preventing its endocytosis and vacuolar degradation."

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TAO kinases mediate activation of p38 in response to DNA damage

dovechocolate submitted, created time 1 year 9 months (www.nature.com)

Thousand and one amino acid (TAO) kinases are Ste20p-related MAP kinase kinase kinases (MAP3Ks) that activate p38 MAPK. Here we show that the TAO kinases mediate the activation of p38 in response to various genotoxic stimuli. TAO kinases are activated acutely by ionizing radiation, ultraviolet radiation, and hydroxyurea. Full-length and truncated fragments of dominant negative TAOs inhibit the activation of p38 by DNA damage. Inhibition of TAO expression by siRNA also decreases p38 activation by these agents

Submit comment | Blog It | Email It | Keywords: DNA damage G2–M checkpoint MAPKs protein kinases Ste20p homolog