Modelling of the ABL and ARG proteins predicts two functionally critical regions that are natively unfolded.

Cys-Oxidation of Protein Tyrosine Phosphatases: Its Role in Regulation of Signal Transduction and Its Involvement in Human Cancers

MedUnion submitted, created time 1 year 8 months (www.mupnet.com)

Reactive oxygen species (ROS) are currently viewed as secondary messengers that control signal transduction through the post-translational modifications of Cys-oxidation in targeting proteins. The physiological levels of ROS are generated in response to stimulation induced by extracellular ligands. Due to the labile feature of ROS, the effect of protein oxidation is normally transient. Such a character is essential for the precise control of redox-dependent signaling homeostasis

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