davidd submitted, created time 8 months 2 weeks (content.nejm.org)

Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and there is evidence of coevolution of the plasmodium parasite with its host. In humans, pyruvate kinase deficiency is the second most common erythrocyte enzyme disorder. Here, they show that pyruvate kinase deficiency provides protection against infection and replication of P

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