Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice

zibba submitted, created time 1 year 2 months (www.pnas.org)

The signaling lipid, phosphatidylinositol 3,5-bisphosphate(PI(3,5)P2),likely functions in multiple signaling pathways. Here, we report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P2 synthesis.

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