Angiotensin II blockade may reduce risk of skin carcinoma

kavin submitted, created time 4 months 15 hours (www.oncolink.org)

Use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) appears to lower the incidence of basal cell and squamous cell carcinoma among people at high risk, according to a study among U.S. veterans.

Evidence from in vivo and in vitro studies suggests that angiotensin II is a potent angiogenic and growth factor, Dr. Jennifer B. Christian and co-investigators note in the September 3 Journal of the National Cancer Institute, issued online on August 26

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The Hypoxia-Inducible Factor 2 alpha N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo

DanyC submitted, created time 1 year 9 months (mcb.asm.org)

“Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor, consisting of an alpha subunit and a beta subunit, that controls cellular responses to hypoxia. HIF contains two transcriptional activation domains called the N-terminal transactivation domain (NTAD) and the C-terminal transactivation domain (CTAD). HIF alpha is destabilized by prolyl hydroxylation catalyzed by EglN family members. In addition, CTAD function is inhibited by asparagine hydroxylation catalyzed by FIH1. Both hydroxylation reactions are linked to oxygen availability

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Identification and characterization of Birt-Hogg-Dubé associated renal carcinoma

BIOBOSS submitted, created time 1 year 10 months (www3.interscience.wiley.com)

Birt-Hogg-Dubé syndrome is a rare disorder that affects the skin and lungs and increases the risk of certain types of tumors. The condition is characterized by multiple noncancerous (benign) skin tumors, particularly on the face, neck, and upper chest. These growths typically first appear in a person's twenties or thirties and become larger and more numerous over time. Affected individuals also have a higher chance of developing cysts in the lungs and an abnormal accumulation of air in the chest cavity (pneumothorax) that may result in the collapse of a lung

Submit comment | Blog It | Email It | Keywords: Birt-Hogg-Dubé syndrome BHD gene renal cell carcinoma mutation germline gene expression real-time PCR