Adoptive transfer of T(reg) depleted autologous T cells in advanced renal cell carcinoma

Immunology submitted, created time 1 year 1 month (www.ncbi.nlm.nih.gov)

PURPOSE: CD4(+)CD25(+) regulatory T (T(reg)) cells are present in increased numbers in patients with advanced cancer and CD25(+) T cell depletion potentiates tumour immunity in animal models. The aim of this study was to assess the feasibility and safety of adoptive transfer of CD25(+) depleted autologous T cells in patients with advanced renal cell carcinoma and to examine resulting changes in lymphocyte subsets. PATIENTS AND METHODS: Six patients with advanced renal cell carcinoma underwent leukapheresis followed by conditioning chemotherapy with cyclophosphamide and fludarabine

Submit comment | Blog It | Email It | Keywords: T reg cell cancer toxicology renal cell carcinoma (RCC) human renal cell carcinoma (RCC)

Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors

DanyC submitted, created time 1 year 5 months (www.biomedcentral.com)

"The major subtypes of renal epithelial neoplasms display differential aberrant CDH1, PTGS2, and RASSF1A promoter methylation levels. This gene panel might contribute to a more accurate discrimination among common renal tumors, improving preoperative assessment and therapeutic decision-making in patients harboring suspicious renal masses."

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RASSF1A promoter methylation and expression analysis in normal and neoplastic kidney indicates a role in early tumorigenesis

Reviver submitted, created time 1 year 5 months (www.molecular-cancer.com)

"This methylation and expression data support the hypothesis that RASSF1A is involved in early tumorigenesis of renal cell carcinoma."

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Detection Of DNA Copy Number Changes And Oncogenic Signaling Abnormalities From Gene Expression Data Reveals MYC Activation In Renal Cell Carcinoma

addict submitted, created time 1 year 6 months (www.medicalnewstoday.com)

UroToday.com- Genetic studies of familial renal cell carcinoma (RCC) syndromes identified that c-met (type I papillary RCC) and fumarate hydratase (type II papillary RCC) are mutated and contribute to disease progression and metastasis. Whether these gene alterations are important in cases of sporadic papillary RCC remains controversial. Some investigators have suggested that mutations in c-met and fumarate hydratase are quite rare in sporadic papillary RCC.

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[FW]FDA Approves Kidney Cancer Drug

DanyC submitted, created time 1 year 7 months (www.foxnews.com)

Torisel, which contains the active ingredient temsirolimus, was approved based on a study that showed the drug prolonged survival of patients with renal cell carcinoma. The drug is an enzyme inhibitor, a protein that regulates cell production, cell growth and cell survival.

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Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival.

Immunology submitted, created time 1 year 7 months (www.ncbi.nlm.nih.gov)

This article describes the increase of T regulatory cells in the peripheral blood and tumour of renal cell carcinoma patients and confirms a correlation between that increase and survival.

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Recent Progress in the Management of Advanced Renal Cell Carcinoma

cappuccion submitted, created time 1 year 9 months (caonline.amcancersoc.org)

A better understanding of the molecular biology of renal cell carcinoma (RCC) has led to a dramatic paradigm shift in the treatment of patients with metastatic disease. Historically, a nonspecific immune approach using cytokines was employed, but recently this has transitioned to a molecularly-targeted approach against vascular endothelial growth factor (VEGF) and related pathways

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