Development of end stage renal disease following an acute cardiac event

sea-maid submitted, created time 6 months 2 weeks (www.nature.com)

The author determined the rate and risk factors for end-stage renal disease (ESRD) in consecutive patients discharged after a cardiac event in a large, unbiased Canadian cohort that receives universal health coverage.

1 comment | Blog It | Email It | Keywords: kidneys risk factors kidney disease cardiac arrest cardiac events renal disease

RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease

jerry submitted, created time 6 months 4 weeks (diabetes.diabetesjournals.org)

This article tells us that high glucose activates RhoA/Rho-kinase in MCs, leading to downstream AP-1 activation and fibronectin induction. Inhibition of this pathway in vivo prevents the pathologic changes of diabetic nephropathy, supporting a potential role for inhibitors of RhoA/Rho in the treatment of diabetic renal disease.

4 comments | Blog It | Email It | Keywords: renal disease AP-1 kidneys diabetes RhoA Rho diabetic renal disease Rho kinase

Transplantation for renal failure secondary to enteric hyperoxaluria: a case report

crackpot submitted, created time 1 year 6 months (www.jmedicalcasereports.com)

"Enteric hyperoxaluria can lead to renal failure. There have only been a few reports of renal transplantation as treatment of endstage renal disease secondary to enteric hyperoxaluria and results have been mixed. This report describes a patient with Crohn's disease who developed chronic renal failure from enteric hyperoxaluria. He subsequently had a successful renal transplant without any post-operative oxalate related complications and has satisfactory renal function almost three years later. Aggressive pre-transplant hemodialysis was not done

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Should clinicians follow the K/DOQI guidelines for treating hyperphosphatemia with sevelamer?

addict submitted, created time 1 year 6 months (www.nature.com)

The number of patients requiring treatment for end-stage renal disease worldwide is growing, and clinicians are more pressed than ever to justify the cost-effectiveness of dialysis. Despite recent progress in improving the efficacy and outcomes of dialysis, cardiovascular disease remains the leading cause of death and one of the most 'expensive' complications in this population.

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Genotype–Phenotype Correlations in Autosomal Dominant and Autosomal Recessive Polycystic Kidney Disease

medal submitted, created time 1 year 8 months (jasn.asnjournals.org)

"The phenotypes that are associated with the common forms of polycystic kidney disease (PKD)—autosomal dominant (ADPKD) and autosomal recessive (ARPKD)—are highly variable in penetrance. This is in terms of severity of renal disease, which can range from neonatal death to adequate function into old age, characteristics of the liver disease, and other extrarenal manifestations in ADPKD. Influences of the germline mutation are at the genic and allelic levels, but intrafamilial variability indicates that genetic background and environmental factors are also key."

Submit comment | Blog It | Email It | Keywords: phenotype polycystic kidney renal disease genetic background