Stem cells: A new pathway for stem cell aging and renewal

sea-maid submitted, created time 2 months 3 days (www.nature.com)

Stem cells have the potential for self-renewal and are therefore able to persist throughout life in a diverse range of tissues. However, their self-renewing capacity declines with age. What mechanisms are responsible for the differences between young and aging stem cells? The discovery of a novel pathway involving high-mobility group A2 (HMGA2), INK4A and ARF has recently provided exciting new insights.

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