"Suicide victims" brains bear chemical scars of child abuse

kavin submitted, created time 8 months 1 day (www.sciencenews.org)

The study is the first to implicate faulty protein production with child abuse and suicide. The researchers find that child abuse can leave lasting scars on its victims, both physical and psychological. It may also leave chemical marks in the brains of its victims who will later kill themselves. In the brains of suicide victims, early abuse marks genes that encode ribosomal RNA, key gears in the cellular machinery that makes proteins.

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RNAstrand: reading direction of structured RNAs in multiple sequence alignments

crackpot submitted, created time 1 year 7 months (www.almob.org)

"While folding energies of an RNA and its reverse complement are similar, the differences are sufficient at least in conjunction with substitution patterns to discriminate between structured RNAs and their complements. Researchers present here a support vector machine (SVM) that reliably classifies the reading direction of a structured RNA from a multiple sequence alignment and provides a dramatic improvement in classification accuracy over previous approaches. "

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Intranucleolar sites of ribosome biogenesis defined by the localization of early binding ribosomal proteins

DanyC submitted, created time 1 year 7 months (www.jcb.org)

"Considerable efforts are being undertaken to elucidate the processes of ribosome biogenesis. Although various preribosomal RNP complexes have been isolated and molecularly characterized, the order of ribosomal protein (r-protein) addition to the emerging ribosome subunits is largely unknown. Furthermore, the correlation between the ribosome assembly pathway and the structural organization of the dedicated ribosome factory, the nucleolus, is not well established

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