Articles with the keyword: 
Gene mutations reveal schizophrenia's complexity
sea-maid submitted, created time 1 month 2 weeks (www.newscientist.com)
The three largest genetic schizophrenia studies to date have uncovered several ways in which changes to the genome may increase the risk of developing the condition.
The studies bring to light several common variations that increase the risk slightly, and rarer ones that raise it significantly, researchers say. 
Early pregnancy trauma boosts schizophrenia risk
sea-maid submitted, created time 1 month 2 weeks (www.newscientist.com)
Excessive stress is never a good thing, but new research suggests that children of women who suffered severe psychological stress during early pregnancy are more likely to develop schizophrenia. ...
Madness: Price of a Big Brain?
sea-maid submitted, created time 1 month 3 weeks (sciencenow.sciencemag.org)
A new study suggests that the debilitating disease schizophrenia may be a byproduct of the genetic changes that fueled the evolution of the expansive human brain. The idea, still preliminary, is that the massive energy demands of the brain may make it vulnerable to mutations in metabolism-related genes.
Missing DNA Boosts Risk of Schizophrenia
sea-maid submitted, created time 2 months 3 days (sciencenow.sciencemag.org)
Two large studies of schizophrenia patients have yielded the most convincing evidence yet that the disease can be caused by mistakes in genes. The researchers linked a much higher risk for schizophrenia to three chromosomal regions that are missing chunks of DNA. Although only a tiny fraction of patients carried these particular glitches, similar errors may help explain other cases of the disease.
Gene surveys identify schizophrenia triggers
sea-maid submitted, created time 2 months 5 days (www.nature.com)
Rare genetic changes associated with a heightened risk of schizophrenia have been revealed by two independent studies.
The surveys have identified sections of the human genome that, when deleted, can elevate the risk of developing schizophrenia by up to fifteen times compared with the general population.
Sex and Drugs and Singing Mice
Vincent submitted, created time 6 months 2 days (sciencenow.sciencemag.org)
Mice can whistle and chirp like birds--and researchers now say their songs seem to be happy ones. New experiments associate the rodents' ultrasonic chatter with the brain's dopamine-based reward system, and investigators hope that studying the songs may eventually point toward genes behind human emotional disorders such as schizophrenia and autism.
Genetic Link to Schizophrenia Discovered
Sue Wu submitted, created time 6 months 1 week (sciencenow.sciencemag.org)
Researchers have found that people with schizophrenia are far more likely than other people to have a certain type of error in their genes. Scientists believe the finding will help them develop new treatments for schizophrenia and identify young people at high risk of developing the disorder.
It's No Delusion: Evolution May Favor Schizophrenia Genes
wugongliang submitted, created time 10 months 2 weeks (www.sciam.com)
Schizophrenia, the psychotic disorder marked by hallucinations, delusions and cognitive disorganization, affects roughly 1 percent of the U.S. population.* Many of those afflicted, however, also have reduced reproductive fitness, which means they are less likely to pass a genetic profile associated with the condition onto their offspring.
How schizophrenia develops: Major clues discovered
richard submitted, created time 11 months 2 weeks (www.eurekalert.org)
We know that something happens during brain development that contributes to schizophrenia. A glitch in the process that turns genes on and off in the brain -- a specific "epigenetic" flaw -- appears to be part of the problem.
Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence
jimmy submitted, created time 11 months 4 weeks (www.pnas.org)
Schizophrenia is a complex multifactorial brain disorder with a genetic component. Convergent evidence has implicated oxidative stress and glutathione (GSH) deficits in the pathogenesis of this disease. The aim of the present study was to test whether schizophrenia is associated with a deficit of GSH synthesis.
Evidence found for novel brain cell communication
bianjie submitted, created time 1 year 2 months (www.eurekalert.org)
An article published today, July 16, 2007, in Proceedings of the National Academy of Sciences provides strong evidence for a novel type of communication between nerve cells in the brain. The findings may have relevance for the prevention and treatment of epilepsy, and possibly in the exploration of other aspects of brain functions, from creative thought processes to mental illnesses such as schizophrenia. The discovery suggests the first new model of brain function since the 1940s.
angelfish submitted, created time 1 year 3 months (ajp.psychiatryonline.org)
"These results indicate that patients with schizophrenia exhibit white matter abnormalities at the time of their first presentation of psychotic symptoms to mental health services and that these abnormalities degenerate further over the initial years of illness. Given the role that white matter plays in neural communication, the authors suggest that these white matter abnormalities may be a cause of the dysfunctional neural connectivity that has been proposed to underlie the symptoms of schizophrenia."
What Is the Best Approach to Treating Schizophrenia in Developing Countries?
red monkey submitted, created time 1 year 3 months (medicine.plosjournals.org)
"The report found no evidence that the proportion of treated people in the developing world had increased since 1990. There is now a debate among mental health professionals in low-income countries over how best to improve patient care. In this article, three psychiatrists give their different viewpoints on the current status of treatment efforts for schizophrenia in the developing world and the measures that can be taken to increase the proportion of patients receiving treatment."
Substantial Shared Genetic Influences on Schizophrenia and Event-Related Potentials
amanda submitted, created time 1 year 4 months (ajp.psychiatryonline.org)
"Several components of event-related potentials—P50 suppression, P300 amplitude and latency, and mismatch negativity—have been proposed as potential endophenotypes for schizophrenia on the basis of family studies. The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia."
medal submitted, created time 1 year 4 months (archpsyc.ama-assn.org)
"In focusing on potentially localizable cognitive impairments, the schizophrenia meta-analytic literature has overlooked the largest single impairment: on digit symbol coding tasks. "
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