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12

Study identifies genes that protect against aging

piggy submitted, created time 10 months 3 weeks (www.eurekalert.org)

Scientists at the University of Liverpool have developed a new method to help researchers identify genes that can help protect the body during the aging process.

The team developed a method of analyzing genes in several types of aging tissue in both animals and humans. The analysis, which included more than five million gene measurements, highlighted the mechanisms used by the body to protect against age-related cellular changes that can result in muscle degeneration and cognitive aging

11

Aspirin and Similar Drugs May Be Associated with Brain Microbleeds in Older Adults

sea-maid submitted, created time 11 months 6 days (www.eurekalert.org)

Individuals who take aspirin or other medications that prevent blood clotting by inhibiting the accumulation of platelets appear more likely to have tiny, asymptomatic areas of bleeding in the brain, according to a report posted online today that will appear in the June print issue of Archives of Neurology, one of the JAMA/Archives journals.

11

Vitamin D Supplements Associated with Reduced Fracture Risk in Older Adults

sea-maid submitted, created time 11 months 2 weeks (www.sciencedaily.com)

Oral vitamin D supplements at a dose of at least 400 international units per day are associated with a reduced risk of bone fractures in older adults, according to results of a meta-analysis.

11

Not so sweet: Over-consumption of sugar linked to aging

piggy submitted, created time 1 year 1 week (www.eurekalert.org)

We know that lifespan can be extended in animals by restricting calories such as those gleaned from sugar intake. Now, according to a study published in the journal PLoS Genetics, Université de Montréal scientists have discovered that it's not the sugar itself that is important in this process but the ability of cells to sense its presence.

Aging is a complex phenomenon and the mechanisms underlying it have yet to be explained. What researchers do know is that there is a clear relationship between aging and calorie intake

10

B Vitamins Might Lower Stroke Risk

sea-maid submitted, created time 1 year 3 weeks (news.yahoo.com)

who take high doses of B vitamins are somewhat less likely to suffer from stroke, especially if they're under 70, a new Canadian study suggests.

9

Visual Decline As We Age: Genetics or Environment?

sea-maid submitted, created time 1 year 1 month (www.sciencedaily.com)

Which has a larger impact on the "normal" decline of visual function as we age, genetic or environmental factors? This question is explored in the February issue of Ophthalmology, the journal of the American Academy of Ophthalmology.

The study was performed on forty-two sets of twins, twenty-one identical and twenty-one fraternal. There was a strong genetic correlation with functions involving sharp and color vision--things concerning cone cells, but not with night vision or light detection--things concerning rod cells.

11

Feeling Old? Blame Your Nuclear Pores

piggy submitted, created time 1 year 1 month (sciencenow.sciencemag.org)

As if gimpy knees, clogged arteries, and forgetfulness weren't bad enough, new research has identified another way our bodies falter as we get older. The pores that permit only certain molecules to enter and exit the nuclei of our cells start leaking. A new study raises the possibility that permissive pores trigger some of the physical decline of old age.

Nuclear pores aren't mere portholes. Each consists of about thirty different proteins called nucleoporins that control what goes in and out of the nucleus

10

Old gastrointestinal drug slows neurodegenerative diseases

sea-maid submitted, created time 1 year 2 months (www.eurekalert.org)

Recent animal studies have shown that clioquinol – an eighty-year-old drug once used to treat diarrhea and other gastrointestinal disorders – can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases. Scientists, however, had a variety of theories to attempt to explain how a single compound could have such similar effects on three unrelated neurodegenerative disorders.

Researchers at McGill University have discovered a dramatic possible new answer: According to Dr

10

The prevalence of gluten-sensitive enteropathy in iron-deficient anemia patients

sea-maid submitted, created time 1 year 2 months (www.eurekalert.org)

A research group from Iran investigated the prevalence of gluten-sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. They found that there is a high prevalence of GSE in patients with IDA of obscure origin. A gluten-free diet can improve anemia in GSE patients who have mild duodenal lesions without villous atrophy.

11

Brain starvation as we age appears to trigger Alzheimer's

sea-maid submitted, created time 1 year 2 months (esciencenews.com)

A slow, chronic starvation of the brain as we age appears to be one of the major triggers of a biochemical process that causes some forms of Alzheimer's disease. A new study from Northwestern University's Feinberg School of Medicine has found when the brain doesn't get enough sugar glucose -- as might occur when cardiovascular disease restricts blood flow in arteries to the brain -- a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer's.

12

A Little Wine Boosts Omega-3 in the Body: Novel Mechanism for a Healthier Heart Found

piggy submitted, created time 1 year 3 months (www.sciencedaily.com)

Moderate alcohol intake is associated with higher levels of omega-3 fatty acids in plasma and red blood cells. This is the major finding of the European study IMMIDIET that will be published in the January issue of the American Journal of Clinical Nutrition.

The study suggests that wine does better than other alcoholic drinks. This effect could be ascribed to compounds other than alcohol itself, representing a key to understand the mechanism lying behind the heart protection observed in moderate wine drinkers

12

Potentially Universal Mechanism of Aging Identified

piggy submitted, created time 1 year 3 months (www.sciencedaily.com)

Researchers have uncovered what may be a universal cause of aging, one that applies to both single-celled organisms such as yeast and multicellular organisms, including mammals. This is the first time that such an evolutionarily conserved aging mechanism has been identified between such diverse organisms.

The mechanism probably dates back more than one billion years. The study shows how DNA damage eventually leads to a breakdown in the cell's ability to properly regulate which genes are switched on and off in particular settings

12

Unusual Signs You'll Live longer Than You Imagined

sea-maid submitted, created time 1 year 3 months (www.reuters.com)

With my 40th birthday looming ahead of me in the next few weeks I do sometimes think (not to be morbid or anything) of how long I will live and if my life is half over, etc, etc (you get the point). I saw this article on “Surprising Signs You’ll Live Longer Than You Think” and could not resist sharing it with you. Now, I will say this, I do want to live a long time more (as long as I am in good health and can take care of myself) but I don’t want to outlive everyone in my peer group

13

Spanish scientists create extra-long-lived mice

piggy submitted, created time 1 year 4 months (www.enews20.com)

Spanish scientists have created "super-mice" that are cancer-resistant and live up to forty percent longer, media reported Friday.

The mice were subjected to genetic engineering by researchers from the cancer research centre CNIO and Valencia University.

The key to the experiment was an enzyme called telomerase, which lengthens chromosome ends known as telomeres.

Telomerase allows cells to keep dividing and is believed to increase longevity, but it also heightens the risk of cancer

10

Stem cells: A new pathway for stem cell aging and renewal

sea-maid submitted, created time 1 year 4 months (www.nature.com)

Stem cells have the potential for self-renewal and are therefore able to persist throughout life in a diverse range of tissues. However, their self-renewing capacity declines with age. What mechanisms are responsible for the differences between young and aging stem cells? The discovery of a novel pathway involving high-mobility group A2 (HMGA2), INK4A and ARF has recently provided exciting new insights.

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