Genome-wide analysis for discovery of rice microRNAs reveals natural antisense microRNAs (nat-miRNAs)

davidd submitted, created time 9 months 1 week (www.pnas.org)

Small RNAs (21–24 nt) are involved in gene regulation through translation inhibition, mRNA cleavage, or directing chromatin modifications. At least five classes of these small regulatory RNAs (21–24 nt) have been characterized. miRNA and siRNA is reported frquently. However, the natural antisense miRNAs (nat-miRNAs) have not been reported in any system.

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Heritable epigenetic mutation of a transposon-flanked Arabidopsis gene due to lack of the chromatin-remodeling factor DDM1

bioman submitted, created time 1 year 5 months (www.nature.com)

"Here, we report a novel mechanism for a ddm1-induced syndrome, called bonsai (bns). We identified the gene responsible for the bns phenotypes by genetic linkage analysis and subsequent transcriptional analysis. The bns phenotypes are due to silencing of a putative Anaphase-Promoting Complex (APC) 13 gene. The BNS gene silencing was associated with DNA hypermethylation, which is in contrast to the ddm1-induced hypomethylation in the other genomic regions. "

Submit comment | Blog It | Email It | Keywords: anaphase promoting complex BONSAI epigenetic inheritance heterochromatin small RNA