Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

william submitted, created time 1 year 2 months (www.pnas.org)

Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix–loop–helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of smooth muscle cell (SMC) differentiation.

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