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WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION

biscuits submitted, created time 1 year 11 months (physics.ucsd.edu)

[Full Text]Water is essential for life in many ways, and without it biomolecules might no longer truly be biomolecules. In particular, water is important to the structure, stability, dynamics, and function of biological macromolecules. In protein folding, water mediates the collapse of the chain and the search for the native topology through a funneled energy landscape. Water actively participates in molecular recognition by mediating the interactions between binding partners and contributes to either enthalpic or entropic stabilization

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