SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing

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With regards to the survival of motor neurons (SMN), certain proteins are essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the major components of the pre-mRNA splicing machinery.

This article suggests that SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing.

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