Tumorigenesis: Keeping a watchful eye

sea-maid submitted, created time 2 months 2 weeks (www.nature.com)

Disruptions in the delicate balance between keratinocyte proliferation and differentiation can contribute towards the development of squamous cell carcinoma (SCC) of the skin — a common human malignancy. It has been proposed that innate surveillants, molecules that promote terminal keratinocyte differentiation, exist in the skin to prevent carcinogenesis, but the conclusive identification of such proteins has not yet been achieved

Submit comment | Blog It | Email It | Keywords: squamous cell carcinoma squamous cell carcinomas keratinocytes skin cells skin tumorigenesis tumors cancer Human skin cells

Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway

sea-maid submitted, created time 4 months 3 weeks (www.nature.com)

Fanconi anemia (FA) is a genome instability syndrome that is characterized by progressive bone marrow failure and a high risk of cancer. FA patients are particularly susceptible to leukemia as well as squamous cell carcinomas (SCCs) of the head and neck, anogenital region and skin. This article details experiments exploring the up and downregulation of FA.

Submit comment | Blog It | Email It | Keywords: squamous cell carcinoma leukemia cancer bone marrow anemia Fanconi anemia

Head and neck cancers

kavin submitted, created time 7 months 2 weeks (www.ncbi.nlm.nih.gov)

Most head and neck cancers are squamous cell carcinomas that develop in the upper aerodigestive epithelium after exposure to carcinogens such as tobacco and alcohol. The authors review the epidemiology, molecular pathogenesis, diagnosis and staging, and the latest multimodal management of squamous cell carcinoma of the head and neck.

2 comments | Blog It | Email It | Keywords: cigarettes risk factors alcohol tobacco squamous cell carcinoma squamous cancer cell Head and Neck Cancer

Expression and Prognostic Significance of EpCAM

Cryospray ablation (CSA) in the palliative treatment of squamous cell carcinoma of the esophagus

Scarlett submitted, created time 1 year 9 months (www.wjso.com)

Esophageal carcinoma is the ninth most prevalent cancer worldwide with squamous cell carcinoma (SCCA) and adenocarcinoma accounting for the vast majority of new cases. The study indicated that endoscopic cryo spray ablation warrants further investigation as a palliative treatment modality for esophageal cancer. This is the first reported case in the medical literature.

Submit comment | Blog It | Email It | Keywords: Cryospray ablation squamous cell carcinoma Esophageal carcinoma