Tissue engineering triumph: Doctors transplant a trachea made from the patient's own stem cells

Darkfrog submitted, created time 1 month 2 weeks (www.lancet.com)

The medical journal Lancet has just announced that doctors have performed the first successful trachea transplant using a trachea crafted from the patient's own stem cells. The New York Times is hailing this as a revolutionary step in regenerative medicine. The surgery took place in Barcelona this past June. Researchers from universities in Spain, Britain and Italy collaborated on the preparation. The patient's original trachea--actually one of her bronchi--had been damaged by severe tuberculosis.

Prof

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Wnt Signaling in Polycystic Kidney Disease

medal submitted, created time 1 year 8 months (jasn.asnjournals.org)

"Wnt signaling cascades activate morphogenetic programs that range from cell migration and proliferation to cell fate determination and stem cell renewal. These pathways enable cells to translate environmental cues into the complex cellular programs that are needed to organize tissues and build organs."

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Efficacy and safety of yttrium 90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for autologous stem cell transplantation

Luneetty submitted, created time 1 year 9 months (bloodjournal.hematologylibrary.org)

A prospective, multicenter, nonrandomized phase 2 trial was conducted to evaluate the efficacy and safety of a single dose of yttrium 90 (90Y) ibritumomab tiuxetan in elderly patients in first relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL) ineligible for stem cell transplant. Patients had been previously treated with chemotherapy (group A, n = 76) or chemotherapy plus rituximab (group B, n = 28)

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