Mesolimbic Novelty Processing in Older Adults

addict submitted, created time 1 year 9 months (cercor.oxfordjournals.org)

Normal aging is associated with neuronal loss in the dopaminergic midbrain (substantia nigra/ventral tegmental area, SN/VTA), a region that has recently been implicated in processing novel stimuli as part of a mesolimbic network including the hippocampus. The age-related structural degeneration of the mesolimbic system is quantified by using magnetization transfer ratio (MTR) and correlated it with mesolimbic hemodynamic responses (HRs) to stimulus novelty

Submit comment | Blog It | Email It | Keywords: fMRI hippocampus mesolimbic system novelty substantia nigra&VTA