Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells

scott submitted, created time 1 year 2 months (www.pnas.org)

The T cell receptor (TCR) expressed on most T cells is a protein complex consisting of TCRαβ heterodimers that bind antigen and cluster of differentiation (CD) 3εδ,εγ,and ζζ dimers that initiate signaling.

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Disease-Associated Prion Protein Oligomers Inhibit the 26S Proteasome

athena submitted, created time 1 year 8 months (www.molecule.org)

"The mechanism of cell death in prion disease is unknown but is associated with the production of a misfolded conformer of the prion protein. We report that disease-associated prion protein specifically inhibits the proteolytic β subunits of the 26S proteasome. Using reporter substrates, fluorogenic peptides, and an activity probe for the β subunits, this inhibitory effect was demonstrated in pure 26S proteasome and three different cell lines

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