Novel 3′-phosphoadenosine-5′-phosphatases from extremely halotolerant Hortaea werneckii reveal insight into molecular determinants of salt tolerance of black yeasts

halophiles submitted, created time 1 year 4 months (www.sciencedirect.com)

Two novel 3′-phosphoadenosine-5′-phosphatases, HwHAL2A and HwHAL2B, have been cloned from saltern-inhabited extremely halotolerant yeast Hortaea werneckii, which are ubiquitous enzymes required for the removal of the cytotoxic 3′-phosphoadenosine-5′-phosphate produced during sulfur assimilation in eukaryotes. But addittionally it was shown that they considerably increased the tolerance to sodium and lithium ions when expressed in salt-sensitive S. cerevisiae

1 comment | Blog It | Email It | Keywords: Salt tolerance sulphate metabolism exreme environment phospahtase adaptation yeast agriculture