Complementary receptors control RhoA

sea-maid submitted, created time 6 months 2 weeks (www.jcb.org)

During cell migration, the actin cytoskeleton regulator, RhoA, must be alternately inhibited (to allow the leading membrane edge to protrude) and reactivated (to pull up the trailing end of the cell from behind). Inhibition occurs when a receptor called 5β1 integrin, which binds to the extracellular matrix protein, fibronectin, triggers phosphorylation of a RhoA inhibitor called p190RhoGAP-A (p190-A). Another fibronectin receptor, syndecan-4, colocalizes with integrin during RhoA inhibition, but whether this second receptor contributes to inhibition was unknown.

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