Selective Tuning of the Blood Oxygenation Level-Dependent Response during Simple Target Detection Dissociates Human Frontoparietal Subregions

Reviver submitted, created time 1 year 7 months (www.jneurosci.org)

"Current models of working memory and focal attention converge on the idea of an adaptable global system, distributed across a network of frontal and parietal brain regions. Here, researchers examine how the human frontoparietal network selectively adapts to represent currently relevant information during a simple attentional task: monitoring for a target item in a series of nontargets. Across the entire frontoparietal network, there is selective response to targets, in line with a global system for coding task-relevant inputs

Submit comment | Blog It | Email It | Keywords: target recognition domains (TRDs) metabolic network frontal cortex parietal cortex fMRI

Generation of DNA cleavage specificities of type II restriction endonucleases by reassortment of target recognition domains

annatto submitted, created time 1 year 7 months (www.pnas.org)

"Type II restriction endonucleases (REases) cleave double-stranded DNA at specific sites within or close to their recognition sequences. Shortly after their discovery in 1970, REases have become one of the primary tools in molecular biology. However, the list of available specificities of type II REases is relatively short despite the extensive search for them in natural sources and multiple attempts to artificially change their specificity

Submit comment | Blog It | Email It | Keywords: type II diabetes LAP-4 type target recognition domains (TRDs)