Flu Shots May Cut Risk of Blood Clots Forming in Veins

piggy submitted, created time 1 month 4 weeks (www.sciencedaily.com)

Flu shots may reduce the risk of blood clots forming in veins by 26 percent, according to research presented at the American Heart Association’s Scientific Sessions 2008.

“Our study suggests for the first time that vaccination against influenza may reduce the risk of venous thrombotic embolism (VTE),” said Joseph Emmerich, M.D., Ph.D., lead author of the study and professor of vascular medicine at the University Paris Descartes and head of the INSERM Lab 765, which investigates thrombosis. “This protective effect was more pronounced before the age of fifty-two years

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10 percent of healthy people in study had injury from "silent strokes"

kavin submitted, created time 6 months 1 week (esciencenews.com)

A recent study found that about 10 percent of the apparently healthy middle-aged participants with no symptoms of stroke were injured from "silent strokes," researchers report in Stroke: Journal of the American Heart Association. Silent cerebral infarction (SCI), or "silent stroke," is a brain injury likely caused by a blood clot interrupting blood flow in the brain. It's a risk factor for future strokes and a sign of progressive brain damage that may result in long-term dementia.

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Pollution Boosts Risk of Blood Clots As Well

sea-maid submitted, created time 7 months 3 weeks (www.efluxmedia.com)

In our opinion, it has long been known that pollution has noxious repercussions on our health, but no study stated that it might raise the risk of deep vein thrombosis (DVT) until today. In this study,we can found that the pollution can boost risk of blood clots.

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Development and validation of a predictive model for chemotherapy-associated thrombosis

sea-maid submitted, created time 7 months 3 weeks (bloodjournal.hematologylibrary.org)

Risk of venous thromboembolism (VTE) is elevated in cancer, but individual risk factors cannot identify a sufficiently high-risk group of outpatients for
thromboprophylaxis. The author developed a simple model for predicting chemotherapy-associated VTE using baseline clinical and laboratory variables.

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In the Dark — The Case for Electronic Health Records

Luneetty submitted, created time 1 year 6 months (content.nejm.org)

I sighed as I flipped again through the paperwork sent with my first admission of the night. All I found was a partially legible discharge summary. The patient, a young man who was ventilator dependent and in a vegetative state since receiving a gunshot injury 6 months previously, had been transferred from a nursing home after a workup revealed a new deep venous thrombosis in his leg.

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Incomplete Stent Apposition and Very Late Stent Thrombosis After Drug-Eluting Stent Implantation

medal submitted, created time 1 year 7 months (circ.ahajournals.org)

"Incomplete stent apposition is highly prevalent in patients with very late stent thrombosis after DES implantation, suggesting a role in the pathogenesis of this adverse event. "

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Clinical Outcomes and Stent Thrombosis Following Off-Label Use of Drug-Eluting Stents

badboy submitted, created time 1 year 7 months (jama.ama-assn.org)

"Compared with on-label use, off-label use of drug-eluting stents is associated with a higher rate of adverse outcomes during the index admission and at 1 year. Stent thrombosis occurred predominantly in patients who underwent off-label drug-eluting stent implantation. Clinicians should be cautious about extrapolating the benefits of drug-eluting stents over bare-metal stents observed in randomized clinical trials to higher-risk clinical settings that have not been assessed. "

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Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers

alpha submitted, created time 1 year 8 months (www.jem.org)

"We describe a mouse model of fetal loss in factor V Leiden (FvL) mothers in which fetal loss is triggered when the maternal prothrombotic state coincides with fetal gene defects that reduce activation of the protein C anticoagulant pathway within the placenta. Fetal loss is caused by disruption of placental morphogenesis at the stage of labyrinth layer formation and occurs in the absence of overt placental thrombosis, infarction, or perfusion defects. Platelet depletion or elimination of protease-activated receptor 4 (Par4) from the mother allows normal placentation and prevents fetal loss. "

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Deficiency of Src homology 2 domain–containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth

medal submitted, created time 1 year 8 months (www.jci.org)

"Using SHIP1-deficient mice, we found that its loss affects platelet aggregation in response to several agonists with minor effects on fibrinogen binding and ß3 integrin tyrosine phosphorylation. Accordingly, SHIP1-null mice showed defects in arterial thrombus formation in response to a localized laser-induced injury."

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