Hormone injections can strengthen bones

sumsung submitted, created time 9 months 4 weeks (www.nature.com)

Weekly or semiweekly injections of a hormone that stimulates the thyroid gland can also strengthen bones in rodents, researchers have found. The hormone, called thyroid-stimulating hormone (TSH), is already available as a therapy for thyroid cancer patients, and clinical studies are now under way to determine whether it might also be used to fight the debilitating bone-wasting disease osteoporosis.

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Presence of gene mutation helps guide thyroid cancer treatment

bianjie submitted, created time 1 year 4 months (pub.ucsf.edu)

A specific gene mutation may be useful in predicting the level of aggression of thyroid cancer and help guide treatment options and follow-up care, according to new study findings.

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Gene Methylation in Thyroid Tumorigenesis

athena submitted, created time 1 year 10 months (endo.endojournals.org)

Aberrant gene methylation plays an important role in human tumorigenesis, including thyroid tumorigenesis. Many tumor suppressor genes are aberrantly methylated in thyroid cancer, and some even in benign thyroid tumors, suggesting a role of this epigenetic event in early thyroid tumorigenesis. Methylation of some of these genes tends to occur in certain types of thyroid cancer and is related to specific signaling pathways.

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The Paired Box-8/Peroxisome Proliferator-Activated Receptor- Oncogene in Thyroid Tumorigenesis

athena submitted, created time 1 year 10 months (endo.endojournals.org)

"A proportion of FTC has been found to be associated with a chromosomal translocation, t (2, 3)(q13;p25), which fuses the thyroid-specific transcription factor paired box-8 with the peroxisome proliferator-activated receptor- nuclear receptor, a ubiquitously expressed transcription factor. This fusion event causes expression of a paired box-8/peroxisome proliferator-activated receptor- fusion protein (PPFP). PPFP is detected in approximately 30% of FTC

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AKT in Thyroid Tumorigenesis and Progression

fiona submitted, created time 1 year 10 months (endo.endojournals.org)

Protein kinase B is a central signaling molecule in the phosphatidyl inositol 3-kinase pathway that is frequently activated in human cancer. AKT activation regulates energy metabolism, apoptosis, proliferation, and migration in many cell systems. In thyroid cancer, AKT activation is involved in tumorigenesis, particularly in both inherited and sporadic forms of follicular thyroid cancer.

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