Hepatic gene expression changes in hypothyroid juvenile mice

broadcast submitted, created time 1 year 8 months (endo.endojournals.org)

"The molecular mechanisms involved in the response of developing mice to disruptions in maternal thyroid hormone (TH) homeostasis are poorly characterized. We used DNA microarrays to examine a broad spectrum of genes from the livers of mice rendered hypothyroid by treating pregnant mice from gestational day (GD) 13 to post-natal day (PND) 15 with 6-propyl-2-thiouracil (PTU) in drinking water."

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