Articles with the keyword: 
Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis
stephen submitted, created time 1 year 2 months (www.pnas.org)
SUMOylation of transcription factors often attenuates transcription activity. This regulation of protein activity allows more diversity in the control of gene expression. Interferon regulatory factor-1 (IRF-1) was originally identified as a regulator of IFN-α/β, and its expression is induced by viral infection or IFN stimulation. 
Dmbx1 is essential in agouti-related protein action
jackson submitted, created time 1 year 3 months (www.pnas.org)
Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1-/- mouse from its cohabitants induces self-starvation, sometimes leading to death, features similar to those of anorexia nervosa in humans.
kitty submitted, created time 1 year 3 months (www.pnas.org)
Previous reports suggested that humans and mice differ in their sensitivity to the genetic dosage of transcription factors that play a role in early testicular development. This difference implies that testis determination might be somewhat different in these two species.
GATA-1 and Gfi-1B Interplay To Regulate Bcl-xL Transcription
annatto submitted, created time 1 year 7 months (mcb.asm.org)
"The induction of Bcl-xL is critical for the survival of late proerythroblasts. The erythroid-specific transcriptional network that regulates Bcl-xL expression in erythropoiesis remains unclear. The activation of the central erythropoietic transcriptional factor, GATA-1, leads to the early, transient induction of a transcription repressor, Gfi-1B, followed by the late induction of Bcl-xL during erythroid maturation in G1ER cells
NELF Interacts with CBC and Participates in 3′ End Processing of Replication-Dependent Histone mRNAs
athena submitted, created time 1 year 7 months (www.molecule.org)
"Negative elongation factor (NELF) is a four subunit transcription elongation factor that has been implicated in numerous diseases ranging from neurological disorders to cancer. Here we show that NELF interacts with the nuclear cap binding complex (CBC), a multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3′ end processing of replication-dependent histone mRNAs, most likely through association with the histone stem-loop binding protein (SLBP)
ETS transcription factors in endocrine systems
fiona submitted, created time 1 year 7 months (www.sciencedirect.com)
"E26 transformation-specific (ETS) transcription factors have become increasingly recognized as key regulators of differentiation, hormone responses and tumorigenesis in endocrine organs and target tissues. The ETS family is highly diverse, consisting of both transcription activators and repressors that mediate growth factor signaling and regulate gene expression through combinatorial interactions with multiple protein partners on composite DNA elements
Control of peripheral B-cell development
athena submitted, created time 1 year 8 months (www.sciencedirect.com)
"Three subsets of mature B cells exist in mice: B-1, follicular and marginal zone B cells. The recruitment of newly formed transitional B cells into these compartments depends on signals emanating from the B-cell antigen receptor, possibly in response to (self-)antigen recognition. Recent evidence suggests that peripheral B-cell fate is controlled by B-cell antigen receptor signal strength, acting in concert with the cytokine B-cell activating factor
Hypoxia signalling controls metabolic demand
amanda submitted, created time 1 year 8 months (www.sciencedirect.com)
"It has been known for quite some time that cancer cells undergo far-reaching modifications in their metabolism, yet a full understanding of these changes and how they come about remains elusive. Even under conditions of plentiful oxygen, cancer cells choose to switch glucose metabolism from respiration to lactic acid formation. The mystery behind the molecular mechanisms of this phenomenon, known as the Warburg effect, is now being unravelled
julie submitted, created time 1 year 8 months (www.molecule.org)
"Surprisingly, the physiological consequences of altering calcineurin-Crz1 affinity depend on the growth conditions. Crz1PVIVIT improves yeast growth under several environmental stress conditions but causes a growth defect during alkaline stress, most likely by titrating calcineurin away from other substrates or regulators."
collapsar submitted, created time 1 year 8 months (hmg.oxfordjournals.org)
SOX9 is a temporal and tissue-specific transcription factor involved in male sexual development and bone formation. Haploinsufficiency of SOX9 is known to cause campomelic dysplasia (CD). CD cases without SOX9 coding region mutations have been described in association with translocations that have breakpoints mapping as far as 932 kb upstream from the gene. These rearrangements suggest position effects acting from a great distance regulate SOX9 gene expression
Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas
amanda submitted, created time 1 year 9 months (diabetes.diabetesjournals.org)
"The transcription factor regulatory factor X (RFX)-3 regulates the expression of genes required for the growth and function of cilia.“
Transcriptional regulation in early B cell development
medal submitted, created time 1 year 9 months (www.sciencedirect.com)
"Transcription factors and signalling molecules are important for both lineage commitment and lineage-specific regulation. The B cell specification factor Pax5 plays a dual role in B lineage commitment. Simultaneously, it potentiates and limits lineage choice by activating genes that are required for the B cell program while repressing lineage-inappropriate genes; more than 100 of the latter have now been identified."
Commissure formation in the mammalian forebrain
amanda submitted, created time 1 year 9 months (www.sciencedirect.com)
"Commissural formation in the mammalian brain is highly organised and regulated both by the cell-autonomous expression of transcription factors, and by non-cell-autonomous mechanisms including the formation of midline glial structures and their expression of specific axon guidance molecules."
medal submitted, created time 1 year 9 months (mbe.oxfordjournals.org)
"Recent investigations on metazoan transcription factors (TFs) indicate that single-gene duplication events and the gain and loss of protein domains are 2 crucial factors in shaping their protein–protein interaction networks. Plant genomes, on the other hand, have a history of polyploidy and whole-genome duplications (WGDs), and thus, their study helps to understand whether WGDs have also had a significant influence on protein network evolution. "
DanyC submitted, created time 1 year 9 months (mcb.asm.org)
“Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor, consisting of an alpha subunit and a beta subunit, that controls cellular responses to hypoxia. HIF contains two transcriptional activation domains called the N-terminal transactivation domain (NTAD) and the C-terminal transactivation domain (CTAD). HIF alpha is destabilized by prolyl hydroxylation catalyzed by EglN family members. In addition, CTAD function is inhibited by asparagine hydroxylation catalyzed by FIH1. Both hydroxylation reactions are linked to oxygen availability
abuse@discover8.com
angelfish
Darkfrog
jane2007
kavin
Sue Wu
addict
β-Casomorphin is an opioid peptide. It was first isolat ...
www.genscript.com
HA lysates
293 cells transfected with HA-tagged minigene, 55 kDa. 100 u ...
www.genscript.com
Smart His-tagged Protein Standard
The Smart His-tagged Potein Standard is a lyophilized mixtur ...
www.genscript.com
Rabbit Anti Akt (Ab-473) (polyclonal)
antibody : Rabbit Anti Akt (Ab-473) (polyclonal)
www.genscript.com